BASINI Giuseppina, GRASSELLI Francesca
-Ovarian angiogenic mechanisms in pigs: The sequence of events that culminates in the formation of new vascular structures from pre-existing capillaries appears to be crucial in ovarian physiology; in addition, the ovary represents an interesting model of physiological angiogenesis.
-Swine ovarian follicle as a model for endocrine disruption: Endocrine disrupters are a large, heterogeneous and still not fully-known group of substances, both synthetic and natural. They all alter the endocrine system by displaying multiple and not yet fully understood mechanism of action. Their effects on reproductive function are particularly insidious.
BERTINI Simone, MENOZZI Alessandro
-Clinical efficacy of rifaximin and new therapeutic approaches in chronic enteropathies of small animals
-Effects of drugs (NSAIDs, opioid analgesics, alpha-2 agonists, muscarinic antagonists) on bronchial and intestinal motility “in vitro” in horses
-Detection of contaminants (lead and copper derived from hunting ammunitions) in game meat
-HPLC analysis of antibiotic and antiparasitic drugs in plasma and tissues
BOTTI Maddalena, CACCHIOLI Antonio, GAZZA Ferdinando, RAGIONIERI Luisa, RAVANETTI Francesca
-The study of different tissues (in particular bone, muscular and nervous tissues) and of organs of digestive and uro-genital apparatuses.
-The applied techniques used are histological and histomorphometric (by means of routine staining to define the qualitative and quantitative aspects of tissues), histochemical (by means of procedures that highlight the enzymatic activity of the tissues), immunofluorescent and immunohistochemical (by means of direct or indirect techniques to highlight the expression of specific molecules or structures within different tissues) and SEM and TEM ultrastructural investigations.
-Development of laboratory as well as clinical protocols aimed to the application of regenerative therapies in veterinary medicine. The research is focussed on new approaches for the preparation and administration of mesenchymal stem cells, stromal vascular fraction of adipose tissue and platelet concentrates to be used in dog, cat and horse clinical cases, with particular interest in diseases of the musculoskeletal system, wound healing and chronic ulcers treatments.
-Structure-function relation of bovine, porcine and human Odorant Binding Proteins: the aim is to achieve the structural and functional characterization of the native isoforms and in-vitro produced mutants of vertebrate OBPs. The research is also aimed to develop biotechnological application of the proteins, studying their interaction with molecules of physiological, biomedical and environmental interest.
OSSIPRANDI Maria Cristina
I have published papers concerning epidemiologic studies of potentially zoonotic bacteria in swine (Salmonella spp., Helicobacter spp. and Bacillus cereus), bovine (Staphylococcus aureus) and equine (Clostridium difficile) populations, as well as in pets which were monitored for the presence of Enterococcus, Escherichia coli, Pseudomonas and Proteus, Clostridium difficile and perfringens. I conducted research on molecular profile of Clostridium difficile and perfringens strains in major livestock species in order to define their toxic profile. I carried out specific studies to assess the effectiveness of biomaterials employed in orthopedics and currently the topic corresponds to biodiversity related to gut microbiota in different animal species and possible interactions on human microbiota (bifidobacter population).
Investigation of the structural and functional properties of native and mutated forms of mammalian odorant binding protein (OBP). This is a soluble polypeptide secreted in the mucus layering the epithelia of the respiratory apparatus, where it exerts the role of scavenger for odorous molecules and other toxic compounds therein produced in consequence of the oxidative stress (for instance 4-hydroxi-2-noenal). Due to is broad ligand binding specificity, OBP has been employed as a protein retention element of a filter for the removal of traces of triazine herbicides from water. This finding represents the base for its biotechnological application in the field of ultrapure water production.
-Endocrinology of domestic animals.
-Somatotropic axis and immune system development in swine.
-Endocrine function of adipose tissue.